Arturo Vidal is important to Chile and the fact that he has strugged to complete training this week is a worry for Sampaoli.
After the 6-0 defeat in a friendly against France in October, Australia coach Holger Osieck was sacked and replaced by Ange Postecoglou.
It will be interesting to see whether he can turn around the general negativity back home over the Socceroos’ hopes of qualifying from such a difficult group.
Postecoglou will rely heavily on Mile Jedinak, crucial in Crystal Palace’s late season renaissance under Tony Pulis.
He relishes the physical battle, as does Australia’s top scorer of all time Tim Cahill.
Though they also face Spain and Holland, Chile have been tipped by some experts as a good outside bet for a long run in the tournament.
England saw their strengths at Wembley, and with conditions favouring La Roja, they should start with a win against Australia.
The Socceroos are really just making up the numbers in this group and will be delighted if they avoid another France-style thrashing in their three games.
Stat of the game: Australia have scored just eight goals in 10 games at three World Cup final tournaments, winning only two.
Chile (Possible, 3-4-3): Bravo; Jara, Medel, Gonzalez; Isla, Vidal, Diaz, Beausejour; Sanchez, Vargas, Fernandez.
Test: Vidal (knee).
Australia (Possible, 4-3-3): Ryan; Franjic, Spiranovic, McGowan, Davidson; Milligan, Jedinak, Bresciano; Halloran, Cahill, Oar.
Referee: Noumandiez Doue (Ivory Coast).