Hernandez, Mexico’s third all-time scorer, with 35 goals, has been struggling in front of goal of late.
Cameroon are without Mohamadou Idrissou, one of the five players to be dropped from Cameroon’s final squad for the World Cup.
The 34-year-old Kaiserslautern striker has struggled in recent times and missed a penalty in a 2-1 friendly loss to Paraguay recently.
Late qualifiers meet late arrivals in Natal.
Mexico only just maintained their record of qualifying for every World Cup since 1990, voa the play-offs, while Cameroon’s players initially refused to board the plane for Brazil until an agreeement could be reached over bonus payments.
Both teams know it will be hard to get out of Group A and neither will have great expectations for getting further than the last 16 – but they could determine who goes through.
Stat of the game: Cameroon’s Fabrice Olinga, at 18 years and one month, is the youngest player at the finals and, if selected, will become the ninth-youngest in World Cup history.
Mexico (Possible, 4-4-2): Talavera; Moreno, Layun, Reyes, Salcido; Vazquez, Herrera, Giovani dos Santos, Guardado; Pulido, Jimenez.
Cameroon (Possible, 4-4-2): Itandje; Assou-Ekotto, Djeugoue, Nkoulou, Enoh; Mbia, Song, Moukandjo, Matip; Eto’o, Webo.
Referee: Wilmar Roldan (Colombia).