Rooney sat out the 1-0 defeat to Sunderland as he was struggling with a stomach bug and groin injury, but he could feature against Steve Bruce’s side.
Interim player-manager Ryan Giggs could name himself in the match day squad for the final home game of the season, but goalkeeper Anders Lindegaard and defender Rafael are doubts.
Meanwhile, Hull manager Steve Bruce is set to ring the changes at Old Trafford, with Premier League safety now assured.
Bruce has an FA Cup final to plan for on May 17 and will take the chance to give the likes of Stephen Quinn, George Boyd, Robert Koren, Yannick Sagbo and Matty Fryatt some much-needed game time.
Defender James Chester, Soné Aluko, Allan McGregor, Robbie Brady and Paul McShane are all out.
This could signal the end of an evra for several United stalwarts.
Rio Ferdinand wants to stay but his contract is up while Nemanja Vidic is leaving to join Inter Milan.
And, with Louis van Gaal expected to be named as United’s manager, the future of Ryan Giggs remains unclear.
He could surrender to sentiment and feature for United in what could be his last ever appearance at Old Trafford.
Hull, meanwhile, will be hoping to avoid an embarrassement with the FA Cup final less than a fortnight away.
Steve Bruce returns to Old Trafford as manager of Hull; what price the likeable Geordie one day being manager at his former club?
Stat of the game: Hull have never won in the league at Old Trafford, losing nine and drawing one of 10 visits. And United have won their last six league games against Hull home and away.
Manchester United (Possible, 4-4-1-1): De Gea; Rafael, Jones, Vidic, Evra; Nani, Carrick, Fletcher, Kagawa; Mata; Van Persie.
Out:: Lindegaard (illness), Rafael (thigh)
Hull City (Possible, 4-4-2): Harper; Rosenior, Bruce, Davies, Figueroa; Elmohamady, Quinn, Livermore, Boyd; Sagbo, Fryatt.
Out:: Aluko (ankle), Brady (groin), Chester (hamstring), McGregor (kidneys/ribs), McShane (ankle).
Referee: Craig Pawson. Matches: 9, R0 Y26.