Stoke recorded a comfortable 2-0 win against United on Boxing Day but their promising form has taken a dip since the turn of the new year.

Defeat at Leicester City – which marked their second successive away league loss – preceded bitter knock- disappointment this week, as they were beaten on penalties by Liverpool in the League Cup semi-final before exiting the FA Cup at the hands of Crystal Palace on Saturday.

“It’s been a difficult week for us all to be perfectly honest,” manager Mark Hughes, who will take charge of his 100th league match as Stoke manager on Tuesday, told their official website.

“I can’t fault the players’ effort – they gave it a real go [against Palace] – but we just lacked that quality that we needed.”

United hope to have Bastian Schweinsteiger back from knee trouble and Matteo Darmian is recovering well from a heavy collision against Southampton but Phil Jones, Antonio Valencia (both ankle), Ashley Young (groin), Luke Shaw (leg fracture) and Marcos Rojo (shoulder) are out.

Stoke’s hopes of recording a first league win at Old Trafford were dealt a blow when Marc Wilson suffered a knee injury, which Hughes fears could keep him sidelined for some weeks.

With captain Ryan Shawcross (back) and Charlie Adam (calf) out, and doubts over Marko Arnautovic (back) and Geoff Cameron (ankle), Hughes’ hopes of ending an eight-game losing streak away to his old club appear to be slim, despite United’s own problems.